Tetrahydroxystilbene glucoside
2,3,5,4'-tetrahydroxyl diphenylethylene-2-o-glucoside
CAS: 82373-94-2
Molecular Formula: C20H22O9
Tetrahydroxystilbene glucoside - Names and Identifiers
| Name | 2,3,5,4'-tetrahydroxyl diphenylethylene-2-o-glucoside |
| Synonyms | THSG EH-201 CHEMBL460860 Astragalus polyphenols Tetrahydroxystilbene glucoside 2,3,4,5-Tetrahydroxystilbene 2-glucoside 2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucopyranosid 2,3,5,4'-tetrahydroxyl diphenylethylene-2-o-glucoside 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside 2,4-Dihydroxy-6-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-Glucopyranoside |
| CAS | 82373-94-2 |
| EINECS | 683-231-5 |
Tetrahydroxystilbene glucoside - Physico-chemical Properties
| Molecular Formula | C20H22O9 |
| Molar Mass | 406.38 |
| Density | 1.593±0.06 g/cm3(Predicted) |
| Melting Point | 184-186°C |
| Boling Point | 715.0±60.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.63 in Me2CO)+73 |
| Solubility | Soluble in methanol, ethanol |
| Appearance | powder |
| Color | white to brown |
| pKa | 8.78±0.40(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00238694 |
| Physical and Chemical Properties | Chemical properties like white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Polygonum multiflorum. |
| Use | Uses Stilbene glycoside has the effects of brain protection, scavenging free radicals, lowering blood lipids, liver protection, anti-tumor, vasodilating, and inhibiting atherosclerosis. |
Tetrahydroxystilbene glucoside - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29389090 |
Tetrahydroxystilbene glucoside - Reference
| Reference Show more | 1. Zhang chunlao, Cao Bin, Luo Guoping, et al. Determination of stilbene glycoside in Shouwu sugar-free granules by HPLC [J]. Applied Chemical engineering 2018 047(001):203-205. 2. The estrogen-like effect of stilbene glucoside and its effect on the expression of ER in the uterus of immature mice [J]. China pharmacy 2019 30(08):29-34. 3. Li Xixi, Li feilang, Xiyuan, Yiyan. Polygonum multiflorum saponins antagonize h_2o_2-induced oxidative damage in rat hippocampal neurons by activating BDNF/TrkB signaling pathway [J]. Natural product research and development 2019 31(07):1163-1169. 4. Bai Junqi, Huang Zhihai, Huang Juan, et al. An example of the exploration of the precise boiling powder of rhizome Chinese medicine-the preparation of Polygonum multiflorum [J]. World Science and Technology: modernization of traditional Chinese medicine, 2017(19):95-100. 5. Liu Meiting, Li Qian, Qu Minhong et al. Study on HPLC fingerprint of Polygonum multiflorum and radix polygoni multiflori [J]. West China Pharmaceutical Journal 2018v.33(02):89-92. 6. Hou Jianwei, Ding, Yue, Zhang Tong, et al. Simultaneous determination of three active components in tiaogengtang by HPLC-DAD method [J]. Chinese patent medicine 2014 36(7):1454-1457. 7. Wang, Jing, Yue, Zhang, fan, Chai, Chong, et al. Correlation between the color of Polygonum multiflorum Thunb and the contents of anthraquinones and stilbene glycoside [J]. Central South pharmacy 2020(4). 8. Li Jiaxing, Jin Yan, et al. Determination of nine stilbene glycosides in radix polygoni multiflori by UPLC-MS/MS [J]. Chinese herbal medicine 2018 41(006):1395-1398. 9. Li Jiaxing et al. Determination of 10 stilbene glycosides in Polygonum multiflorum Thunb by UPLC-MS/MS [J]. Chinese Journal of Experimental prescriptions 2018(23):87-92. 10. GE, Zhao, Liang, Cheng, gang, Yu, Jianping, Xu, Dujuan. Effects of traditional processing on the main chemical components of Polygonum multiflorum Thunb. [J]. Modern Chinese medicine research and practice 2017 31(03):43-47. 11. Wang Liping, Zhang Huailiang. Simultaneous determination of six components in Tianma Xifeng granules by HPLC [J]. Journal of Medicine Forum 2018 v.39(06):20-23. 12. Cheng, Su, Pan, Zhang, Min-min Liang Yan et al. Analysis of chemical components in Anshen Bunao liquid by HPLC-DAD-ESI-TOF/MS [J]. Chinese patent medicine 2019 041(004):743-748. 13. Zhu Gan, Wang Yan, Li Yaofeng, Fu Yunyan, Tang Wencao, Yang Changfu, Wang Shengsheng. Effects of stilbene glucoside on proliferation and estrogen receptor expression of human breast cancer T-47D cells [J]. China Pharmacy, 2020,31(19):2315-2320. 14. Zhou Gui, Xie Ruifang, Yu Tianyuan, Zhou Xin. Establishment of fingerprint and determination of three components of caulis polygoni multiflori [J]. Chinese Medicine Guide, 2020,26(13):27-32. 15. Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qin, 2,3,5,4 '-Tetrahydroxystilbene-2-O-β-d-glucoside stores BDNF-TrkB and FGF2-Akt Signaling Axis to ate Stress-induced Depression, Neuroscience, Volume 430,2020, Pages 25-3 16. Yun Yu et [IF = 5.396] al."2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside attenuates MPP /MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis."Food Funct. 2019 Sep;10(9):6009-6019 17. [IF=4.411] Tao Tian et al."Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose."Molecules. 2021 Jan;26(15):4638 18. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577 19. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 20. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal-Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321-5328 21. [IF=3.056] Xi-Xi Li et al."2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression."Neuroscience. 2020 Mar;430:25 22. [IF=2.523] Teng-Teng Ren et al."2,3,5,4'-tetrahydoxystilbene-2-O-β-D-glucoside eliminates staurosporine-induced cytotoxicity restoring BDNF-TrkB/Akt signaling axis."Int J Med Sci. 2020; 17(14): 2207-2213 23. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 24. [IF=5.811] Kong Wei-Song et al."Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury."Front Pharmacol. 2022 Apr;0:928 |
Tetrahydroxystilbene glucoside - Uses and synthesis methods
Introduction
stilbene glycoside, also known as stilbene polyphenols, belongs to polyhydroxystilbene compounds (polyhydrostilbenes) and widely exists in moss and advanced plants. Stilbene glycoside has been identified as a phytoalexin, which is produced by plants under unfavorable conditions such as fungal infection, ultraviolet radiation, and mechanical damage. Studies have found that stilbene glycosides have a variety of physiological activities and medicinal values, and have shown functionality in lowering blood lipids, anti-aging, and inhibiting, which highlights its important research and development value in today's aging society.
biological activity
2,3,4 ', 5-tetrahydroxystibilbene 2-O-D-glucoside is isolated from the roots of Polygonum species and can inhibit the formation of 5-HETE, HHT and thromboxane B2.
Last Update：2024-04-10 22:29:15
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